The 27th Wisconsin Infantry mustered in at Camp Sigel in Milwaukee. It would go on to participate in the siege of Vicksburg, Mississippi, and the capture of Little Rock, Arkansas. At the end of the war, it would fight in the campaign against Mobile, Alabama, including the siege of Spanish Fort and the assault and capture of Fort Blakely. The regiment lost 259 men in a little more than two years. Twenty-two enlisted men were killed in combat, and five officers and 232 enlisted men died from disease.