The 33rd Wisconsin Infantry left Wisconsin for The South. It would go on to serve in Mississippi, Arkansas, Missouri, and Louisiana. It participated in the sieges of Jackson and Vicksburg, the Red River Expedition, the Battle of Nashville, the siege of Spanish Fort and the capture of Fort Blakely. It would lose 202 men during service. Three officers and 30 enlisted men were killed. Two officers and 167 enlisted men died from disease.